WebJun 25, 2014 · Hydrophobic effects are ubiquitous and manifest themselves in everyday processes such as solubilizing oil, precipitating molecules, and formation of particles or … WebProtScale ProtScale [Reference / Documentation] allows you to compute and represent the profile produced by any amino acid scale on a selected protein.. An amino acid scale is defined by a numerical value assigned to each type of amino acid. The most frequently used scales are the hydrophobicity or hydrophilicity scales and the secondary structure …

Hydrophobic Interaction Chromatography and Modeling of Protein ...

Nowadays, automated receptor–ligand docking is widely used in studies of molecular mechanisms of protein—small compound interactions and in drug design (Moitessier et al., 2008). However, the insufficient accuracy of the scoring functions may result in the loss of perspective ligands since near-native … See more The empirical MHP concept used in PLATINUM to calculate molecular hydrophobic/hydrophilic properties is based on atomic hydrophobicity … See more The input to PLATINUM is a 3D structure of a receptor molecule in a separate file and a set of ligand poses. If more than one ligand was uploaded, e.g. when … See more The PLATINUM web service provides flexible tools for calculation and visualization of molecular hydrophobic/hydrophilic properties in receptor–ligand … See more Webhydrophobic interaction becomes a thermodynami cally favorable process. In conclusion, the hydrophobic interaction between two or more non-polar molecules in a polar solvent solution is a spontaneous process governed by a change in entropy. Accordingly, hydrophobic interactions can be weakened by raising temperature or by modifying the pirha yritystunnus

Distance-dependent hydrophobic-hydrophobic contacts in protein …

WebThe signaling phosphatidylinositol lipids PI (4,5)P2 (PIP2) and PI (3,4,5)P3 (PIP3) bind nuclear receptor 5A family (NR5As), but their regulatory mechanisms remain unknown. Here, the crystal structures of human NR5A1 (steroidogenic factor-1, SF-1) ligand binding domain (LBD) bound to PIP2 and PIP3 show the lipid hydrophobic tails sequestered in ... WebHow to develop a purification workflow for a protein expressed in E. coli using hydrophobic interaction chromatography (HIC) ... The salt concentration was varied from 100 to 800 … WebJul 4, 2008 · The interaction of guest molecules ranging from pentan-1-ol to octan-1-ol with α-cyclodextrin (α-CD) in water of has been studied calorimetrically at 283.15, 288.15, 293.15, 298.15 and 308.15 K with an isoperibolic titration calorimeter designed in our laboratory. The calorimetric method employed allows the determination of the thermodynamic … pirha töihin