Improving protein succinylation sites
WebFeb 1, 2024 · Of all succinylation proteins identified, 48.1% (312/649) possessed only one modified site, 21.4% (139/649) had two succinylated peptide sites, 9.9% (64/649) contained three sites, and 1.2% (8/649) of modified proteins have 10 or more sites (see Figure 1A ). The average degree of succinylation sites per protein was 2.4 (1557/649). WebOct 31, 2024 · Lysine succinylation is a newly discovered protein post-translational modifications. Predicting succinylation sites helps investigate the metabolic disease treatments. However, the biological experimental approaches are costly and inefficient, it is necessary to develop efficient computational approaches. In this paper, we proposed a …
Improving protein succinylation sites
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WebImproving protein succinylation sites prediction using embeddings from protein language model Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, regulation, and repair. WebProtein succinylation is a type of post-translational modification (PTM) that occurs on lysine sites and plays a key role in protein conformation regulation and cellular function control.
WebAug 18, 2024 · Abstract. Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including … WebOct 8, 2024 · Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, …
WebApr 23, 2024 · Using an independent test set of experimentally identified succinylation sites, our method achieved efficiency scores of 79%, 68.7% and 0.48 for sensitivity, specificity … WebOct 8, 2024 · Europe PMC is an archive of life sciences journal literature.
WebThe potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than acetylation (42 Da) or methylation (14 Da), it is expected to lead to more significant changes in protein structure and …
WebDownload scientific diagram Two Sample Logos of the succinylation lysine sites compared to unlabeled sites. Different color of symbles represents different physical and chemical properties ... port douglas holiday packages with flightsWebOct 8, 2024 · A novel approach that combines features from supervised word embedding with embedding from a protein language model called ProtT5-XL-UniRef50 in a deep learning framework to predict protein succinylation sites is presented. Protein succinylation is an important post-translational modification (PTM) responsible for many vital … port douglas horse ridingWebSuccinylation, which is among the more recently discovered PTMs, is comparatively unique 3. Like methyla-tion, acetylation or ubiquitination, succinylation also occurs on lysine … port douglas glass bottom boatWebApr 7, 2016 · A new predictor named pSuc-FFSEA, which can predict succinylation sites in protein sequences by feature fusion and stacking ensemble algorithm is developed, which showed excellent robustness and performed better than the previous prediction tools. 2 PDF irish song about winning first placeWebOct 21, 2024 · Succinylation can improve the solubility of milk protein concentrate and sodium caseinate. The result of differential calorimetry scanning illustrated that the … irish song about a weddingWebFeb 4, 2024 · Succinylation is achieved by non-enzymatic processes or by a series of enzymes [like p300, lysine acetyltransferase 2A (KAT2A)] that transfer the succinyl groups from succinyl-coenzyme A (CoA) to the specific lysine, modulating protein function in various physiological processes [ 1 ]. irish song lyrics and music midiWebAug 15, 2024 · In 2013, through the research of Park et al., 2565 protein succinylation sites were identified in 779 proteins, and their experimental results showed that the enzymes produced by lysine succinylation had potential effects on the metabolic function of mitochondria, such as the degradation of amino acids, the circulation of tricarboxylic … irish song lyrics printable