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Dynamics of gene expression in single

WebNov 18, 2024 · Despite advances in single-cell analysis, dynamics and topology of the cell cycle in high-dimensional gene expression space remain largely unknown. We developed a linear analysis of transcriptome data which reveals that cells move along a planar circular trajectory in transcriptome space during the cycle. WebFeb 9, 2024 · Single Cell Dynamics Group is interested in understanding why genetically identical cells respond heterogenous to environmental stimuli. Recent research suggests that in diseases, such as cancer or the process of aging, expression variability increases in tissue. Determining the factors and mechanisms that regulate this variability will help us ...

Developmental and conditional dynamics of gene …

WebJul 18, 2024 · Here we examine an established population of human adipose-derived stem cells (ASCs) using a novel, microfluidic-based method for high-throughput transcriptional interrogation, coupled with advanced bioinformatic analysis, to evaluate the dynamics of single cell gene expression among primary, passage 0, and passage 1 stem cells. WebOct 22, 2024 · Single-cell RNA-seq can yield high-resolution cell-type-specific expression signatures that reveal new cell types and the developmental trajectories of cell lineages. … bisecur hormann https://pozd.net

Dynamic gene expression and growth underlie cell-to-cell …

WebMay 11, 2024 · By modelling gene expression as a Gaussian process, two competing models of single cell dynamics were proposed. An OU model describes random aperiodic fluctuations, but in contrast to white noise the fluctuations are correlated over time, and this may form a more appropriate model of non-oscillating single cells for statistical testing. WebJul 18, 2024 · Here we examine an established population of human adipose-derived stem cells (ASCs) using a novel, microfluidic-based method for high-throughput transcriptional … WebTo decipher cell state transitions from single-cell transcriptomes it is crucial to quantify weak expression of lineage-determining factors, which requires computational methods that are sensitive to the variability of weakly expressed genes. ... Revealing dynamics of gene expression variability in cell state space Nat Methods. 2024 Jan;17(1 ... bise dg khan 10th result

Integrative Single‐Cell Transcriptomics and Epigenomics Mapping …

Category:Generalizing RNA velocity to transient cell states …

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Dynamics of gene expression in single

Comparative analysis of noise-attenuation mechanisms in gene …

WebFeb 21, 2024 · In the study described here, we used single-cell RNA sequencing (scRNA-seq) to study gene expression dynamics in human fetal kidney development. Analysis … WebFeb 21, 2024 · In the study described here, we used single-cell RNA sequencing (scRNA-seq) to study gene expression dynamics in human fetal kidney development. Analysis of a fetal kidney from week 16 (w16) …

Dynamics of gene expression in single

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WebNov 18, 2024 · Abstract. To decipher cell state transitions from single-cell transcriptomes it is crucial to quantify weak expression of lineage-determining factors, which requires computational methods that are ... WebMar 12, 2024 · Dissimilarity matrix and local alignment between expression dynamics of a single gene module along LPS (left to right) and PAM (top to bottom) trajectories under similarity threshold of 0.25 of ...

WebAbstract Time series of single-cell transcriptome measurements can reveal dynamic features of cell differentiation pathways. From measurements of whole frog embryos spanning zygotic genome activation through early organogenesis, we derived a detailed catalog of cell states in vertebrate development and a map of differentiation across all … WebDynamics of Gene Expression in Single Root Cells of Arabidopsis thaliana Ken Jean-Baptiste,a José L. McFaline-Figueroa,a Cristina M. Alexandre,a Michael W. Dorrity,a Lauren Saunders,a Kerry L. Bubb,a Cole Trapnell,a Stanley Fields,a,b Christine Queitsch,a and Josh T. Cuperusa,1 a Department of Genome Sciences, University of Washington, …

WebJul 21, 2006 · Dynamics of single-cell gene expression D Longo and J Hasty 2 Molecular Systems Biology 2006 &2006 EMBO and Nature Publishing Group. networks, setting the stage for the systematic construction of synthetic gene networks of increasing complexity, which mimic the behavior of naturally occurring systems. Webearly embryo, new gene expression generally arises in single contiguous domains. To askwhether the single-cell gene expression states conform to a branching pattern and, if …

WebWe focused on stress-response genes in Escherichia coli to study the dynamics of expression and growth in single cells. Genes involved in adaptation to stress are …

WebThe underlying mechanisms that determine gene expression and chromatin accessibility in retinogenesis are poorly understood. Herein, single-cell RNA sequencing and single … bised portfolioWebOct 1, 2011 · Single-Cell Gene Expression. (a) Dynamics of the prolactin promoter in rat pituitary cells observed by measuring the activity of a luciferase reporter ... It is the first study to interrogate gene expression dynamics on a scale that allowed comparison across eukaryotic genes, leading to the conclusion that kinetic signatures were highly gene ... bis edusprint loginWebMar 28, 2024 · 1 1 RESEARCH ARTICLE 2 3 Dynamics of Gene Expression in Single Root Cells of A. thaliana 4 5 6 Ken Jean-Baptiste1, José L. McFaline-Figueroa1, Cristina … dark chocolate frosting easyWebJun 11, 2024 · Gene expression programs are dynamic, e.g. the cell cycle, response to stimuli, normal differentiation and development, etc. However, nearly all techniques for … dark chocolate frosting for browniesWebAug 15, 2008 · Here, we are interested in the dynamics of such a switching process on the single cell level. We study these dynamics in the context of the arabinose utilization (ara) system of E. coli (11), another well-characterized bistable system (see Fig. 1).In this case, arabinose is imported by the high-affinity low-capacity transporter AraFGH and the low … bisedyWebOct 26, 2024 · The use of the MS2-MCP approach to monitoring multiple steps of the RNA life cycle in real-time has provided unprecedented insights into the process of gene expression . Analysis of protein turnover by fluorescent probes was widely performed to elucidate gene expression as well (22, 23). However, to explore chromatin dynamics … dark chocolate frostingWebApr 14, 2024 · The determination of the gene clusters revealed the correspondence between RNA kinetics and gene functions. This is indeed a remarkable and groundbreaking method, as it will now aid researchers in probing intricate questions concerning the dynamics of the transcriptome and gene expression regulation. dark chocolate frosting for cupcakes